The current coronavirus outbreak is the biggest challenge for the world since World War Two, UN secretary general António Guterres has warned.
He said it could bring a recession "that probably has no parallel in the recent past".
His warning comes amid dire predictions about the possible economic impact of measures imposed to fight the virus.
The number of confirmed cases around the world is now nearing 860,000, with more than 42,000 deaths.
The death toll in the US is now more than 4,000 - higher than the declared number of fatalities in China, where the outbreak began late last year.
Johns Hopkins University said 865 people had died in the past 24 hours in the US and in all more than 189,000 people in the country had been infected.
About three out of four Americans are now, or about to be, under some form of lockdown, as more US states tighten measures to fight the coronavirus, which causes the Covid-19 disease.
Meanwhile, Spain, second only to Italy in the number of recorded fatalities, has seen 849 deaths in the last 24 hours - the highest number it has had in a single day.
In the UK, a total of 1,789 people have died - a rise of 381, officials say. Among the victims was a 13-year-old boy, King's College Hospital Trust in London said.
What did Mr Guterres say?
Speaking at the UN headquarters in New York at the launch of a report on the potential socioeconomic impact of the outbreak, Mr Guterres said: "The new coronavirus disease is attacking societies at their core, claiming lives and people's livelihoods".
Countries around the world have imposed a series of measures, including restricting people's movements and closing most businesses, to curb the spread of the virus.
The UN report estimates that up to 25 million jobs could be lost around the world as the result of the outbreak. It also projects an up to 40 per cent "downward pressure" on global foreign direct investment flows.
"Covid-19 is the greatest test that we have faced together since the formation of the United Nations," he said, calling for "an immediate co-ordinated health response to suppress transmission and end the pandemic".
Mr Guterres urged the industrialised nations to help those less developed, or potentially "face the nightmare of the disease spreading like wildfire".
On Tuesday, the World Bank warned that "significant economic pain" seemed "unavoidable in all countries", and households that depend on industries particularly vulnerable to the impact of the virus were at "higher risk".