Hong Kong International Airport cancelled all departures on Monday, as thousands of anti-government protesters occupied and caused disruption.
Passengers have been told not to travel to the airport, which is one of the world's busiest transport hubs, reports BBC.
In a statement, officials blamed "seriously disrupted" operations.
Many of those protesting are critical of the actions of police, who on Sunday were filmed firing tear gas and non-lethal ammunition at close range.
Some protesters wore bandages over their eyes in response to images of a woman bleeding heavily from her eye on Sunday, having reportedly been shot by a police projectile
In a statement on Monday afternoon, Hong Kong's Airport Authority said they were cancelling all flights that were not yet checked in.
More than 160 flights scheduled to leave after 18:00 local time (10:00 GMT) will now not depart
Officials said arrivals already heading into Hong Kong would still be allowed to land, but other scheduled flights have been cancelled.