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At least 19 people died after a bus crashed into a ditch in Madaripur, according to the local authorities.
The Dhaka-bound bus operated by Emad Paribahan veered out of control on an expressway, the police said. The death toll is expected to climb.
Another 30 passengers were injured in the accident.
Madaripur Police Superintendent Md Masud Alam said the injured passengers were admitted to different hospitals.
Police and the Fire Service and Civil Defence launched rescue efforts. The dead and the injured are yet to be identified.