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Major stock indexes eased on Thursday as Brent oil futures rose above $105 a barrel, with Iran's denial of any talks with the US dimming hopes of a quick resolution to the nearly one-month-long Middle East war.
Global debt markets also sold off, pushing yields higher, while safe-haven buying boosted the US dollar.
Prospects of a prolonged war in the Middle East fanned worries about energy supply disruptions. Oil and European natural gas rose, with Brent futuresLCOc1 up $4.77 at $106.99 a barrel and US crude futures CLc1 up at $93.64.
US President Donald Trump warned Iran on Thursday to "get serious" about a deal to end nearly four weeks of fighting.
Iran's Foreign Minister Abbas Araqchi had earlier said Tehran was reviewing the US proposal but that there were no talks on winding down the war. Iran on Thursday launched multiple waves of missiles at Israel.
The war, triggered by US–Israeli strikes on Iran in late February, has rattled global markets and effectively shut the Strait of Hormuz, a conduit for a fifth of global oil and liquefied natural gas flows.
Stocks fell "as oil prices resumed their upward climb", said Peter Cardillo, chief market economist at Spartan Capital Securities in New York.
"Unfortunately, we're in a market that's being driven by oil prices. The rhetoric back and forth is continuing, and until talks begin, the market is going to be subject to the price of oil," he said.
The Dow Jones Industrial Average .DJI fell 75.50 points, or 0.19 percent, to 46,342.69, the S&P 500 fell 43.59 points, or 0.68 percent, to 6,547.14 and the Nasdaq Composite .IXIC fell 216.95 points, or 1.02 percent, to 21,705.16.
MSCI's gauge of stocks across the globe .MIWD00000PUS dropped 6.75 points, or 0.68 percent, to 988.71. The pan-European STOXX 600 index fell 0.64 percent.
Japan's Nikkei ended down 0.3 percent, while worries over rising energy costs hammered South Korea's KOSPI, which slumped 3.2 percent. Hong Kong's Hang Seng fell 1.9 percent and China's blue chips dropped 1.3 percent.
The Philippines held an unscheduled central bank meeting due to the turmoil, while Germany's central bank head said an ECB rate hike next month was "an option".
Fears of a 2022-style inflation shock have seen traders fully price out any chance of a Federal Reserve rate cut this year, further supporting the dollar.
Germany's two-year bond yield DE2YT=RR, sensitive to European Central Bank rate expectations, rose after falling on Wednesday. Bond yields move inversely to prices.
Worries about persistent inflation also drove US Treasury yields higher. The benchmark US 10-year Treasury yield US10YT=RR was last up 4.2 basis points at 4.37 percent. The two-year note's yield US2YT=RR was last up 5.4 bps at 3.934 percent.
Earlier, the yield on Japan's two-year government bond JP2YT=RR hit its highest level in 30 years at 1.33 percent, as traders cemented bets on another Bank of Japan rate hike as early as next month.
In currencies, the US dollar rose against most major currencies, reviving its safe-haven appeal.