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At least 42 people were killed in Israeli attacks on districts of Gaza City in the north of the Palestinian enclave on Saturday, the director of the Hamas-run government media office said.
One Israeli strike on houses in Al-Shati, one of the Gaza Strip's eight historic refugee camps, killed 24 people, Ismail Al-Thawabta told Reuters. Another 18 Palestinians were killed in a strike on houses in the Al-Tuffah neighbourhood.
The Israeli military released a brief statement saying: "A short while ago, IDF fighter jets struck two Hamas military infrastructure sites in the area of Gaza City."
It said more details would be released soon.
Hamas did not comment on the Israeli claim to have hit its military infrastructure. It said in a statement the attacks targeted the civilian population and vowed in a statement "the occupation and its Nazi leaders will pay the price for their violations against our people."
Footage obtained by Reuters showed dozens of Palestinians rushing out to search for victims amid the destroyed houses. The footage showed wrecked homes, blasted walls, and debris and dust filling the street in Shati refugee camp.
Israel's ground and air campaign in Gaza was triggered when Hamas-led militants stormed into southern Israel on Oct 7, killing around 1,200 people and seizing more than 250 hostages, according to Israeli tallies.
The offensive has left Gaza in ruins, killed more than 37,400 people, of whom 101 were killed in the past 24 hours, according to Palestinian health authorities, and left nearly the entire population homeless and destitute.
More than eight months into the war, Israel's advance is now focused on the two last areas its forces had yet to seize: Rafah on Gaza's southern edge and the area surrounding Deir al-Balah in the centre.
Residents said Israeli tanks deepened their incursion into western and northern Rafah areas in recent days. On Saturday Israeli forces bombed several areas from air and the ground, forcing many families living in areas described as humanitarian-designated zones to leave northwards.
The Israeli military said forces continued "precise, intelligence-based" targeted operations in Rafah, killing many Palestinian gunmen and dismantling military infrastructure.
On Friday, the Gaza health ministry said at least 25 Palestinians were killed in Mawasi in western Rafah and 50 wounded. Palestinians said a tank shell hit a tent housing displaced families.
The Israeli military said that the incident was under review. "An initial inquiry conducted suggests that there is no indication that a strike was carried out by the IDF (Israel Defence Forces) in the Humanitarian Area in Al-Mawasi," it said.